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Creators/Authors contains: "Gruppuso, Philip A"

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  1. ; ; ; ; ; ; ; ; ; ; et al (, American Journal of Physiology-Gastrointestinal and Liver Physiology)
    We demonstrate that ischemia-reperfusion injury occurs in all livers during NMP, though there are notable differences in gene expression between functional and nonfunctional livers. We further demonstrate that activation of the liver’s repair and homeostasis mechanisms through autophagy plays a vital role in the graft’s response to injury and may impact liver function. These findings indicate that liver autophagy might be a key therapeutic target for rehabilitating the function of severely injured or untransplantable livers. 
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